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What is inflammation?
Inflammation is an auto-immune response to injury or infection in which the body’s white blood cells and chemicals protect us from infection and foreign substances (i.e. bacteria and viruses). The inflammatory response has one all-important goal: respond immediately to detect and destroy infection or toxic material in damaged tissue before it can spread to other areas of the body. In its zeal to protect the body, inflammation will destroy as much tissue as necessary to accomplish this goal. A hyperactive inflammatory response can even react to the traumatic effects of accidents, burns or surgery on the body, attacking healthy tissue.
Left untreated, chronic inflammation can be prevalent in joint conditions where no bacteria are present, attacking healthy tissue such as cartilage, ligaments and even bone. This leads to chronic joint diseases such as arthritis, tendonitis and bursitis. Inflammation can also become systemic and affect processes throughout the body, leading to heart attack, stroke, and fluid in the lungs, asthma and more.
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What are symptoms of inflammation?
Inflammation is typically characterized by redness, swollen joints that are warm to the touch, pain, stiffness and loss of function. It is common for only a few symptoms to be present.
What is Ibunex?
Ibunex is a unique, topically applied formula. One measured pump (0.2g) contains approximately 10mg Ibuprofen plus 4mg Glucosamine, 4mg Chondroitin, 5mg MSM and 5mg Bromelain, formulated with our proprietary Liposomal Dermal Deliver Matrix™ (LDDM).
Ibunex, a topical cream, contains Ibuprofen, MSM, Bromelain, Chondroitin Sulfate, and Glucosamine Sulfate. The synergistic affects of this unique formula target the area of concern, avoiding negative side effects including stomach upset associated with over-the-counter medications taken orally.
What does each of the ingredients do?
Ibuprofen blocks the production of prostaglandins by inhibiting a substance in the body called cyclo-oxygenase (COX). By inhibiting prostaglandins, ibuprofen reduces the messengers involved in the inflammatory response.
Glucosamine Sulfate is a substance found naturally in the body. It is a naturally occurring amino sugar synthesized in the body from L-glutamine and glucose, and is believed to play a role in cartilage formation and repair.
Chondroitin Sulfate is a substance found naturally in the body. Chondroitin sulfate is part of a large protein molecule (proteoglycan) that gives cartilage elasticity. It does this by attracting and holding fluid within the cartilaginous tissue. This helps keep the cartilage healthy by carrying nutrients to the cartilage and protecting the cartilage from wear and tear. The cartilage in the joints of the human body has no blood vessels, so it must receive its nutrients from tissue fluid.
MSM is a compound that contains sulfur. Flexible tissues like connective tissue and cartilage contain proteins with flexible sulfur bonds. Like glucosamine sulfate, this sulfur compound helps in the building of articular cartilage and production of synovial fluid. The latest independent double-blind study found the combination of glucosamine sulfate and MSM greatly superior to either supplement when used individually.
Bromelain is a naturally occurring organic proteolytic enzyme extracted from pineapple that interferes with the arachidonic acid cascade, which is responsible for the production of the pro-inflammatory prostaglandins. Rather than blocking the arachidonic acid cascade at the enzyme cyclo-oxygenase, Bromelain may selectively decrease thromboxane generation and change the ratio of thromboxane/prostacyclin (PGI2) in favor of prostacyclin.
How does the Liposomal Dermal Delivery Matrix™ (LDDM) formula work?
The Liposomal Dermal Delivery Matrix™ (LDDM) penetrates the skin quickly and carries key bioavailable ingredients to the target area using liposome carriers, avoiding the digestive system.
What are liposomes and how do they work?
Liposomes are fatty droplets made artificially in a laboratory by the addition of a water solution to a phospholipid gel. Liposomes are then used to encapsulate ingredients, formulating a delivery system for topical applications. The ingredient is carried within the hollow space created by the encapsulation.
In liposomes, a hydrophilic ingredient can be trapped in aqueous channels that course between successive phospholipid bilayers, whereas a hydrophobic ingredient can reside within the bilayer itself.
Liposomes have the advantage of primarily consisting of lecithin and cholesterol, which are materials that occur naturally in the human body, and thus have good bioacceptability. Once absorbed into the tissue, the nontoxic, nonimmunogenic bilayers of the liposome dissipate, allowing slow diffusion of the ingredient at the targeted area.
Liposomes have an additional advantage when they accumulate in inflamed tissue where endothelial barriers break down, thus making them an excellent delivery system for ingredients targeted toward inflammation.
As opposed to typical oral delivery, where less than 1 percent of an ingredient releases into the area intended for the therapy, and the rest goes through the kidneys, liver and other tissues throughout the body, liposome delivery systems focus concentrated ingredients directly onto the targeted area, avoiding the GI tract entirely.
What is Gluconex?
Gluconex is a unique, topically applied supplementation formula. One measured pump (0.2g) contains 10mg Glucosamine plus 5mg Chondroitin, 5mg, MSM and 5mg Bromelain formulated with our proprietary Liposomal Dermal Deliver Matrix™ (LDDM).
Gluconex addresses chronic joint disorders and inflammation by administering Glucosamine Sulfate, Chondroitin Sulfate, MSM and Bromelain directly to the targeted site.
Why both Ibunex and Gluconex?
Inflammation has 2 phases, acute and chronic. While the acute phase is relatively nondestructive as compared to the chronic stage, it is the precursor to tissue degeneration from chronic inflammation. This chronic stage is the period in which long term damage is sustained within the joint from the degenerative effects of ongoing inflammation.
Ibunex is used 1st during the acute stage (up to 14 days) to target the area of concern and begin introduction of Glucosamine and Chondroitin. Gluconex is then used as a long term maintenance supplementation to help supply the area with ample doses of glucosamine and chondroitin for joint health, along with bromelain for inflammation, and MSM for joint cartilage. This is an excellent long term health regimen that facilitates critical joint supplementation.
What are analgesics?
Analgesics interrupt the pain stimulus, or the brains ability to recognize the pain stimulus. Analgesics are a class of drugs which are used to only relieve pain. They act on physiology by being a “counter-irritant”. The pain relief induced by analgesics occurs either by blocking pain signals going to the brain or by interfering with the brain's interpretation of the signals, without producing anesthesia or loss of consciousness. There are basically two kinds of analgesics: non-narcotics and narcotics.
Acetaminophen (the generic name of the drug found in such brands as Tylenol and Excedrin), is the most commonly used analgesic. Acetaminophen is available over-the-counter and also is often used in combination with other narcotic drugs in some of the stronger analgesics. The most prevalent analgesics on the market are:
- Acetaminophen ( Tylenol, Panadol, Tylenol Arthritis and Excedrin)
- Codeine and Codeine with Acetaminophen (Tylenol #2,3,4)
- Darvon (Propoxyphene)
- Darvocet (Propoxyphene with Acetaminophen)
- Duragesic (Fentanyl Skin Patch)
- Hydromorphone (Palladone)
- Morphine Sulphate (MS Contin)
- Oxycodone (OxyContin)
- Percocet (Oxycodone with Acetaminophen)
- Percodan (Oxycodone with Aspirin)
- Talwin NX (Pentazocine and Naloxone)
- Ultram (Tramadol)
- Ultracet (Tramadol with Acetaminophen)
- Vicodin (Hydrocodone with Acetaminophen)
Many OTC analgesics contain the active ingredients: lidocain, menthol, camphor, peppermint, wintergreen, spearmint and other herbal ingredients believed to have “counter-irritant” effects.
It should be noted that some references to analgesics include aspirin and other non-steroidal anti-inflammatory drugs (NSAIDS) in the class of analgesics, because they have pain reducing properties. Aspirin and NSAIDS primarily have an anti-inflammatory effect, which acts on physiology in a different manner than that of analgesics. Unlike the various NSAIDs (non-steroidal anti-inflammatory drugs) and the Cox-2 inhibitors, which help relieve both pain and inflammation, analgesics only target pain.
What are the concerns of using topical analgesics that heat or cool?
Analgesics do not address the injury but instead only mask the pain resulting from the injury. This leaves the inflammatory process unaffected, allowing it to advance to a chronic condition, leading to critical joint deterioration.
Ibunex and Gluconex are formulated specifically to target the injury. No analgesics are used in these products.
What are NSAIDS?
NSAIDs (nonsteroidal anti-inflammatory drugs) are used to treat inflammation and degenerative diseases like arthritis. NSAIDs work by blocking the activity of the enzyme, cyclo-oxygenase, also known as COX. There are two forms of COX, known as COX-1 and COX-2. COX-2 is involved in the inflammation pathway and is the primary focus of NSAIDs.
NSAIDs arrest inflammation by stopping the production of COX, thus preventing prostaglandins (which cause an inflammatory response) from being formed. NSAIDs differ from analgesics in that NSAIDs work by stopping the inflammatory response that is the source of the pain. Analgesics act as counter-irritants by interrupting the pain stimulus or the brains ability to recognize the pain stimulus.
There are 3 types of NSAIDs:
- Traditional NSAIDs include:
- Ansaid (Flurbiprofen)
- Arthrotec (Diclofenac/Misoprostol)
- Cataflam (Diclofenac Potassium)
- Clinoril (Sulindac)
- Daypro (Oxaprozin)
- Dolobid (Diflunisal)
- Feldene (Piroxicam)
- Ibuprofen (Motrin, Advil)
- Indocin (Indomethacin)
- Ketoprofen (Orudis)
- Lodine (Etodolac)
- Meclomen (Meclofenamate)
- Mobic (Meloxicam)
- Nalfon (Fenoprofen)
- Naproxen (Naprosyn, Aleve)
- Ponstel (Mefanamic Acid)
- Relafen (Nabumetone)
- Tolectin (Tolmetin)
- Voltaren (Dicolfenac Sodium)
- COX-2 Inhibitors include:
- Celebrex (Celecoxib)
- Vioxx (Rofecoxib)(no longer on market)
- Bextra (Valdecoxib)(no longer on market)
- Salicylates (both acetylated, such as aspirin and nonacetylated)
Why are the orally administered forms of NSAIDs bad for the digestive tract?
NSAIDs work by blocking the production of Cox-1 and Cox-2. When NSAIDs are taken orally, they stop the body’s production of Cox-1 in the stomach, which is necessary for the production of mucus. Lack of mucus in the stomach can result in ulcers and bleeding.
Unlike orally administered NSAIDs, Ibunex and Gluconex do not deliver high concentrations of ingredients directly into the GI tract. Oral forms must deliver high levels of ingredients into the GI tract because of the inefficiencies that occur during digestion and absorption.
Orally administrated NSAIDs have the 2 fold problem of having ingredients that can have adverse effects to the GI tract itself, and they must also possess high levels of ingredients in order for oral administration to reach detectable amounts of bioavailability. Because of these characteristics, patients taking oral forms can experience adverse digestive effects.
What are the problems associated with the long term use of orally administrated Cox-2 inhibitors?
Long-term use of orally administrated Cox-2 inhibitors is now associated with a higher risk of strokes and heart attacks because of their systemic characteristics.
Why is the ingredient strength so much lower than over the counter oral medicines?
Oral forms must be administered in much higher amounts for 2 reasons. First, oral forms of medications and supplementations are subject to limited absorption factors in the GI tract, often accounting for less than 20% absorption rates. Secondly, oral forms then become systemic, and are subject to proportional reduction throughout the entire body. This can result in as little as 1/10th of a percent actually reaching a target.
Topical forms are engineered to be applied directly to the target site with absorption rates approaching 95%, concentrating the formula directly on the intended site. This highly efficient delivery method allows for smaller amounts to be applied topically, resulting in a very high concentration at the target site of injury and inflammation.
Do you have research backing up your product?
We do not have research specific to the Ibunex and Gluconex formulas. We have found research documentation regarding key ingredients in the formulas and their effects in oral and topical applications. These studies’ abstracts are available via direct links on our website (www.coreproductslaboratories.com).
Can a bottle be used for multiple individuals?
Yes, the formula comes in a pump delivery system, eliminating the need for package to skin contact, preventing possible skin contaminants transferring from user to user. All bottles are uniform in strength, allowing each user to apply their own intended amount for their specific injury.
How many pumps are there per bottle of Ibunex and Gluconex?
Both Ibunex and Gluconex have 270 pumps per bottle.
How many doctors are using the products?
We do not publicize our sales information. We can tell you that these products are used in numerous practices with compelling results.
Can this be used on children?
It is indicated for adults and children 12 years of age and older.
Can this be used on women who are pregnant?
No, it is not recommended for women who are pregnant, or during lactation.
Does this have any effect on menstrual cycle?
No, a female may use these products at any time during her cycle.
How do I use a single application packet?
The single application packet is simply torn open, and the contents are squeezed onto the target site. The patient then uses their index finger to massage the lotion into the targeted area. The remainder and packaging are safe for disposal in any trash.
Can I use more than one single application packet per day?
Yes, a single use packet contains a large single dose application. This is intended to address a range of conditions including any that involve a large body area. You do not necessarily need to apply the entire amount from the single use packet to address a small target area. This means a single use packet should be effective for 1 to 2 applications depending on amount used. You may apply Ibunex up to 4 times per day, waiting 3 to 4 hours between each application.
Can sunlight affect area applied?
No, our products do not possess characteristics that would cause your skin to become more sensitive to the sun than it normally is. After application it is best to wait 5 to 6 minutes until full absorption has been achieved before exposing the area to the sun as sunlight may induce excessive drying to the area and affect
Can I wash treated area immediately after application?
No, after application it is best to wait 30 minutes before washing targeted area. Washing skin immediately after application may affect upper layers of epidermis that still have application absorption physiology taking place, reducing the efficacy of the ingredients.
Can these products be used with over the counter medicines?
You should not need both forms for the targeted sites of the topically applied Ibunex. If your problem is more systemic and the topical Ibunex is just being introduced, then it is safe to use both forms with the goal being to reduce and then eliminate the orally administered form.
Gluconex should be considered for this type of person as the goal is to establish a long term regimen free of consistent use of oral medicines, and one that focuses on joint health in addition to pain management.
Can Ibunex be used with other Prescription Medications?
You should first ask your prescribing health care provider if OTC NSAIDs containing ibuprofen are safe for you to use. If so, you can then use Ibunex with your prescribed medications.
Does clothing affect the application site?
No, once application site is dry to the touch clothing may be returned, approximately 2-3 minutes.
Diabetic concerns:
Ibunex and Gluconex are safe for use by individuals with type 1 and type 2 diabetes.
Allergic reactions to shellfish concerns:
Ibunex and Gluconex are safe for use by individuals with shellfish related allergies.
Glucosamine is made from Chitin, a carbohydrate. Allergies to shellfish are a result of a protein found in the shellfish, not the carbohydrate. Some people who are allergic to shellfish have reported a reaction to Glucosamine supplements, but this is a result of an impure synthesized form that has traces of proteins in it. Our Glucosamine is free of all shellfish proteins.
Allergic reactions to NSAIDs concerns:
Do not use Ibunex if you are allergic to NSAIDs.
Gluconex is safe for use by individuals with NSAID allergies. Gluconex can be used as an acute inflammatory response therapy for these individuals. Gluconex contains Bromelain, which has anti-inflammatory capabilities, and should be introduced to these individuals as an option for acute therapy in addition to being used for longer-term chronic therapy.
What happens if I apply more than the instructed amount of Ibunex?
For individuals less than 12 years of age, contact your Physician. For individuals 12 years of age and older; Ibunex is safe in cases of accidental exposure of up to 20 applications at 1 time. Exposure to amounts between 20 and 30 applications at 1 time should be watched closely for possible localized skin irritation type reactions. If any symptoms present they should contact their physician. Individuals exposed to greater than 30 applications at 1 time should be advised to consult their physician.
What happens if I apply more than the instructed amount of Gluconex?
For individuals less than 12 years of age, contact your Physician. For individuals 12 years of age and older; Gluconex is safe in cases of accidental exposure of up to 30 applications at 1 time. Exposure to amounts between 30 and 40 applications at 1 time should be watched closely for possible localized skin irritation type reactions. If any symptoms present they should contact their physician. Individuals exposed to greater than 40 applications at 1 time should be advised to consult their physician.
What should an individual do if they accidentally ingested Ibunex or Gluconex?
In most cases small amounts (1 to 10 applications) will be safely digested without incident. If ingested, watch closely for symptoms, especially GI upset. If present, contact your Physician. Individuals ingesting amounts larger than 1 to 10 applications should be advised to contact their physician.
What is the amount of Ibunex ingredients applied with 1 pump?
Ibunex: 1 pump application is 0.2 grams. Ingredients per application:
• Ibuprofen: 10 mg/ pump
• Glucosamine Sulfate: 4 mg/ pump
• Chondroitin Sulfate: 4 mg/ pump
• Bromelain: 5 mg/ pump
• MSM: 5 mg/ pump
What is the amount of Gluconex ingredients applied with 1 pump?
Gluconex: 1 pump application is 0.2 grams. Ingredients per application:
• Glucosamine Sulfate: 10 mg/ pump
• Chondroitin Sulfate: 5 mg/ pump
• MSM: 5 mg/ pump
• Bromelain: 5 mg/ pump
Does weight or target area size effect application amount?
Tissue volume at target size can affect dosage. You should estimate body fat as a percentage of body mass and apply using the following formula:
[1+ (body fat percentage – 10%)] = adjusted amount
(example considering 40% body fat: [1+(40%-10%)]=1.3 times normal application amount)
Product handling instructions:
- Recommended storage temperature range: – 20 to 25°C (68 to 77°F)
- Product is stable from -5°C (23°F) to 120°C (273.6°F).
- In the event that products are stored at or below the maximum temperature threshold, end user should be aware that the viscosity will decrease but will gradually return to normal as the product returns to room temperature. Product may be agitated or stirred to help reestablish the lotions
- Humidity does not affect product
- Package should not to be exposed to direct sunlight for longer than 30 minutes
- Accidental exposure to products poses no health risks outside of Ibunex exposure to individuals with NSAID allergies
- Product packaging allows for safe handling by any individual
- Shelf life: 2 years from expiration date on label
Ibunex application instructions:
Suggested Use: For External Use Only for back, neck, hip and extremity muscles and joints. Unless otherwise prescribed by a health professional, apply 1 to 2 pumps to target area, 3 to 4 pumps for larger areas. Repeat up to 4 times daily, allowing 3-4 hours between applications. Do not use if safety seal is broken. If symptoms persist, consult your health professional. Can be used simultaneously with Gluconex.
Gluconex application instructions:
Suggested Use – For External Use Only for back, hip, extremity muscle and joint maintenance. Unless otherwise prescribed by a health professional, apply 1 to 2 pumps to target area, 3 to 4 pumps to larger areas. Repeat up to 2 times daily, allowing 8-12 hours between applications. Do not use if safety seal is broken. If symptoms persist, consult your health professional. Can be used simultaneously with Ibunex.
How long will a bottle of Ibunex or Gluconex keep?
Both products have a shelf life of at least 2 years, and each bottle is labeled with an expiration date.
The bottles say “Fragrance Free” – what is the slight smell I detect?
The Bromelain ingredient is a naturally occurring organic enzyme extracted from pineapple. Bromelain has a creamy color and slight smell which is natural and indicates the enzyme is working.
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